CaRISMA (PI: Jonassaint)
This research seeks to understand the feasibility of a mobile technology-based behavioral intervention for pain. The intervention we are testing is specifically for individuals living with sickle cell disease (SCD). The goal of this research is to identify a different way of treating pain that does not rely on opioids/narcotics or other medications. The hope is that our research program will lead to the introduction and widespread use of a low-cost, acceptable, and effective behavioral intervention to address chronic pain.

SCD CARRE (PI: Gladwin)
The Sickle Cell Disease and Cardiovascular Risk -Red Cell Exchange Trial, also known as SCD-CARRE, is a study that compares two things: the usual care in SCD patients, and the usual care plus long-term exchange blood transfusion in patients with SCD. Patients with SCD may become anemic because they cannot produce replacement red blood cells as quickly as needed to keep their blood counts in the normal range. A blood transfusion can be given to help increase the red blood cell count to a normal range and increase the blood’s oxygen carrying capacity. It may reduce the risk of strokes and the number of pain crises, or aid healing if a patient has leg ulcers. Approximately 150 patients will participate in this study for 13 months at several major medical centers in the United States, France, and United Kingdom.

Neuropsychology (PI: Novelli)
The aim of the study is to evaluate whether changes in pain intensity reported using a visual analog scale before and after opioid pain treatment, and during regularly scheduled clinic visits, are associated with changes in pain assessed using Painimation, changes in physiological measures assessed with a wearable device and changes in neuropsychological measures.

Tru Pain (PI: Jonassaint)
The purpose of the TRU-Pain study is to help patients and day treatment providers understand acute pain in sickle cell disease patients. The study assesses whether changes in pain intensity reported using a visual analog scale before and after opioid pain treatment, and during regularly scheduled clinic visits, are associated with changes in pain assessed using Painimation, changes in physiological measures assessed with a wearable device, and atmospheric pressure and air temperature at that day. Visual analog scale is a measurement instrument that tries to measure a characteristic or attitude that is believed to range across a continuum of values. In this study, it will be presented as a scale with numbers.